InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Twist2

Summary

InnateDB Protein

IDBP-181551.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Twist2

Protein Name

twist homolog 2 (Drosophila)

Synonyms

bHLHa39; Dermo1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007949

InnateDB Gene

IDBG-181549 (Twist2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010838	positive regulation of keratinocyte proliferation
GO:0032720	negative regulation of tumor necrosis factor production
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0044092	negative regulation of molecular function
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0060325	face morphogenesis
GO:0061303	cornea development in camera-type eye

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:104685

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

PFAM

PF00010

PRINTS

PIRSF

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A5D6P6

UniProt Splice Variant

Entrez Gene

13345

UniGene

RefSeq

NP_031881

MGI ID

MGI Symbol

Twist2

OMIM

CCDS

CCDS15166

HPRD

IMGT

EMBL

AC109197 AC164068 BC090636 CH466520

GenPept

AAH90636 EDL40020