InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Twist2

Summary

InnateDB Gene

IDBG-181549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Twist2

Gene Name

twist homolog 2 (Drosophila)

Synonyms

bHLHa39; Dermo1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007805

Encoded Proteins

IDBP-181551

twist homolog 2 (Drosophila)

IDBP-787903

twist basic helix-loop-helix transcription factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000233608:
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:91801461-91848028

Strand

Forward strand

Band

Transcripts

ENSMUST00000007949	ENSMUSP00000007949
ENSMUST00000186075	ENSMUSP00000139531

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010838	positive regulation of keratinocyte proliferation
GO:0032720	negative regulation of tumor necrosis factor production
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0044092	negative regulation of molecular function
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0060325	face morphogenesis
GO:0061303	cornea development in camera-type eye

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000233608

View Gene Order

ENSBTAG00000021444

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_007855

OMIM

CCDS

CCDS15166

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas