InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhh

Summary

InnateDB Protein

IDBP-181808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhh

Protein Name

desert hedgehog

Synonyms

C78960;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023737

InnateDB Gene

IDBG-181806 (Dhh)

Protein Structure

UniProt Annotation

Function

Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.

Subcellular Localization

Desert hedgehog protein N-product: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Extracellular side {ECO:0000250}. Note=The N-terminal peptide remains associated with the cell surface. {ECO:0000250}.Desert hedgehog protein C-product: Secreted, extracellular space {ECO:0000250}. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in adult testes. Not expressed in limb buds.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005113	patched binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007154	cell communication
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007286	spermatid development
GO:0016539	intein-mediated protein splicing
GO:0030238	male sex determination
GO:0032355	response to estradiol
GO:0033327	Leydig cell differentiation
GO:0042552	myelination
GO:0043627	response to estrogen
GO:0050810	regulation of steroid biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:94891

InterPro

IPR000320 Hedgehog, N-terminal signalling domain
IPR001657 Hedgehog protein
IPR001767 Hedgehog protein, Hint domain
IPR003586 Hint domain C-terminal
IPR003587 Hint domain N-terminal
IPR006141 Intein splice site
IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain
IPR028992 Hedgehog/Intein (Hint) domain

PFAM

PF01085
PF01079

PRINTS

PR00632

PIRSF

PIRSF009400

SMART

SM00305
SM00306

TIGRFAMs

Post-translational Modifications

Modification

Cross-References