InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dhh

Summary

InnateDB Gene

IDBG-181806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhh

Gene Name

desert hedgehog

Synonyms

C78960

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023000

Encoded Proteins

IDBP-181808

desert hedgehog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139549:
This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:98893031-98898540

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023737

ENSMUSP00000023737

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005113	patched binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007154	cell communication
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007286	spermatid development
GO:0016539	intein-mediated protein splicing
GO:0030238	male sex determination
GO:0032355	response to estradiol
GO:0033327	Leydig cell differentiation
GO:0042552	myelination
GO:0043627	response to estrogen
GO:0050810	regulation of steroid biosynthetic process