InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Capn10

Summary

InnateDB Protein

IDBP-182341.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Capn10

Protein Name

calpain 10

Synonyms

AW049679; Capn8; mKIAA1845;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027488

InnateDB Gene

IDBG-182339 (Capn10)

Protein Structure

UniProt Annotation

Function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0031532	actin cytoskeleton reorganization
GO:0032024	positive regulation of insulin secretion
GO:0032388	positive regulation of intracellular transport
GO:0032869	cellular response to insulin stimulus
GO:0046326	positive regulation of glucose import
GO:0097050	type B pancreatic cell apoptotic process
GO:0097194	execution phase of apoptosis
GO:2000676	positive regulation of type B pancreatic cell apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005623	cell
GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1344392

InterPro

IPR001300 Peptidase C2, calpain, catalytic domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family

PFAM

PF00648
PF01067

PRINTS

PR00704

PIRSF

SMART

SM00230
SM00720

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt