Mus musculus Gene: Capn10
Summary
InnateDB Gene IDBG-182339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Capn10
Gene Name calpain 10
Synonyms AW049679; Capn8; mKIAA1845;
Species Mus musculus
Ensembl Gene ENSMUSG00000026270
Encoded Proteins
calpain 10
calpain 10
calpain 10
calpain 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142330:
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:92934376-92947941
Strand Forward strand
Band D
Transcripts
ENSMUST00000027488 ENSMUSP00000027488
ENSMUST00000117814 ENSMUSP00000112831
ENSMUST00000152983 ENSMUSP00000122158
ENSMUST00000128429
ENSMUST00000153828
ENSMUST00000136598
ENSMUST00000187342 ENSMUSP00000141110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0031532 actin cytoskeleton reorganization
GO:0032024 positive regulation of insulin secretion
GO:0032388 positive regulation of intracellular transport
GO:0032869 cellular response to insulin stimulus
GO:0046326 positive regulation of glucose import
GO:0097050 type B pancreatic cell apoptotic process
GO:0097194 execution phase of apoptosis
GO:2000676 positive regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005623 cell
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011796
OMIM
CCDS CCDS15181
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas