InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx4

Summary

InnateDB Protein

IDBP-182736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx4

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Synonyms

AV206478; Mvh; VASA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075157

InnateDB Gene

IDBG-182732 (Ddx4)

Protein Structure

UniProt Annotation

Function

May play a role in germ cell development. May play a role in sperm motility (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22900038}. Cytoplasm, perinuclear region {ECO:0000269PubMed:22900038}.

Disease Associations

Tissue Specificity

Testis. {ECO:0000269PubMed:22900038}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007141	male meiosis I
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0032880	regulation of protein localization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0033391	chromatoid body
GO:0048471	perinuclear region of cytoplasm
GO:0071546	pi-body
GO:0071547	piP-body

Protein Structure and Domains

PDB ID

MGI:102670

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61496