InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddx4

Summary

InnateDB Gene

IDBG-182732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx4

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Synonyms

AV206478; Mvh; VASA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021758

Encoded Proteins

IDBP-182734

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-182736

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152670:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:112598333-112652310

Strand

Reverse strand

Band

D2.2

Transcripts

ENSMUST00000099166	ENSMUSP00000096769
ENSMUST00000075748	ENSMUSP00000075157

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007141	male meiosis I
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030317	sperm motility
GO:0032880	regulation of protein localization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0033391	chromatoid body
GO:0048471	perinuclear region of cytoplasm
GO:0071546	pi-body
GO:0071547	piP-body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000152670

View Gene Order

ENSBTAG00000008871

Not yet available

Cross-References

SwissProt

Q61496

TrEMBL

UniProt Splice Variant

Entrez Gene

13206

UniGene

Mm.12818 Mm.470570

RefSeq

NM_010029 NM_001145885 XM_006517524 XM_006517525 XM_006517526

OMIM

CCDS

CCDS26774 CCDS49366

HPRD

IMGT

MGI ID

MGI:102670

MGI Symbol

Ddx4

EMBL

AK014844 D14859

GenPept

BAA03584 BAB29578

RNA Seq Atlas

13206