Version 5.4
Mus musculus Protein: Polr2m
Summary
InnateDB Protein IDBP-182933.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr2m
Protein Name glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
Synonyms AA407243; AA408799; AI303746; AW553238; D9Wsu138e; Grinl1a; mKIAA4185;
Species Mus musculus
Ensembl Protein ENSMUSP00000034720
InnateDB Gene IDBG-182931 (Polr2m)
Protein Structure
UniProt Annotation
Function Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0032774 RNA biosynthetic process
GO:0051685 maintenance of ER location
Cellular Component
GO:0005635 nuclear envelope
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:107282
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P6I6
PhosphoSite PhosphoSite-Q6P6I6
TrEMBL
UniProt Splice Variant
Entrez Gene 28015
UniGene Mm.403070
RefSeq NP_848717
MGI ID
MGI Symbol Polr2m
OMIM
CCDS CCDS23326
HPRD
IMGT
EMBL AH012404 AK002571 AK014316 AK051868 AK052037 AK079119 AK159924 AK166738 BC018502 BC062199
GenPept AAH18502 AAH62199 AAO15648 BAB22196 BAB29267 BAC34793 BAC34836 BAC37548 BAE35486 BAE38981

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca