InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppap2a

Summary

InnateDB Protein

IDBP-183017.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppap2a

Protein Name

phosphatidic acid phosphatase type 2A

Synonyms

Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a; PAP2-alpha; PAP2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016144

InnateDB Gene

IDBG-183015 (Ppap2a)

Protein Structure

UniProt Annotation

Function

Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Note=Found predominantly in plasma membrane.

Disease Associations

Tissue Specificity

Highly expressed in kidney and lung. Almost undetectable in brain, heart, bone, muscle or spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008195	phosphatidate phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006651	diacylglycerol biosynthetic process
GO:0006670	sphingosine metabolic process
GO:0006672	ceramide metabolic process
GO:0007165	signal transduction