InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppap2a

Summary

InnateDB Gene

IDBG-183015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppap2a

Gene Name

phosphatidic acid phosphatase type 2A

Synonyms

Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a; PAP2-alpha; PAP2a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021759

Encoded Proteins

IDBP-183017

phosphatidic acid phosphatase type 2A

IDBP-183019

phosphatidic acid phosphatase type 2A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067113:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:112800894-112867881

Strand

Forward strand

Band

D2.2

Transcripts

ENSMUST00000016144	ENSMUSP00000016144
ENSMUST00000070951	ENSMUSP00000064423

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008195	phosphatidate phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006651	diacylglycerol biosynthetic process
GO:0006670	sphingosine metabolic process
GO:0006672	ceramide metabolic process
GO:0007165	signal transduction