InnateDB Protein
|
IDBP-183019.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ppap2a
|
Protein Name
|
phosphatidic acid phosphatase type 2A
|
Synonyms
|
Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a; PAP2-alpha; PAP2a;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000064423
|
InnateDB Gene
|
IDBG-183015 (Ppap2a)
|
Protein Structure
|
|
Function |
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P.
|
Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Note=Found predominantly in plasma membrane.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in kidney and lung. Almost undetectable in brain, heart, bone, muscle or spleen.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:108412
|
InterPro |
IPR000326
Phosphatidic acid phosphatase type 2/haloperoxidase
|
PFAM |
PF01569
|
PRINTS |
|
PIRSF |
|
SMART |
SM00014
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q61469
|
PhosphoSite |
PhosphoSite-Q61469
|
TrEMBL |
Q80XY1
|
UniProt Splice Variant |
|
Entrez Gene |
19012
|
UniGene |
|
RefSeq |
NP_032929
|
MGI ID |
|
MGI Symbol |
Ppap2a
|
OMIM |
|
CCDS |
CCDS26777
|
HPRD |
|
IMGT |
|
EMBL |
AK077275
AY247795
AY247796
AY247797
BC061161
D84376
L43371
|
GenPept |
AAA85353
AAH61161
AAP04434
AAP04435
AAP04436
BAA12335
BAC36724
|
|
|