Mus musculus Protein: Sept2
InnateDB Protein IDBP-183378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sept2
Protein Name septin 2
Synonyms AW208991; mKIAA0158; Nedd-5; Nedd5;
Species Mus musculus
Ensembl Protein ENSMUSP00000027495
InnateDB Gene IDBG-183376 (Sept2)
Protein Structure
UniProt Annotation
Function Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements (By similarity). In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. {ECO:0000250, ECO:0000269PubMed:20558667, ECO:0000269PubMed:22179047, ECO:0000269PubMed:9203580}.
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, cilium membrane. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle (By similarity). In interphase and postmitotic cells, localised to fibrous or granular structures, depending on the growth state of the cell. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed.
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030234 enzyme regulator activity
GO:0032947 protein complex scaffold
GO:0042802 identical protein binding
Biological Process
GO:0000910 cytokinesis
GO:0002036 regulation of L-glutamate transport
GO:0006184 GTP catabolic process
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0007224 smoothened signaling pathway
GO:0031175 neuron projection development
GO:0032880 regulation of protein localization
GO:0042384 cilium assembly
GO:0050790 regulation of catalytic activity
GO:0051258 protein polymerization
Cellular Component
GO:0000145 exocyst
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005826 actomyosin contractile ring
GO:0005876 spindle microtubule
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
GO:0031105 septin complex
GO:0032154 cleavage furrow
GO:0035869 ciliary transition zone
GO:0042995 cell projection
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0060170 ciliary membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:97298
InterPro IPR000038 Cell division protein GTP binding
IPR008113 Septin 2
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00735
Post-translational Modifications
SwissProt P42208
PhosphoSite PhosphoSite-P42208
UniProt Splice Variant
Entrez Gene 18000
UniGene Mm.488666
RefSeq XP_006529302
MGI Symbol Sept2
EMBL AC108412 AK028072 AK146616 AK151591 AK171331 BC138636 BC138637 CH466520 D49382
GenPept AAI38637 AAI38638 BAA08380 BAC25737 BAE27305 BAE30531 BAE42396 EDL39946 EDL39948