Version 5.4
Mus musculus Protein: Cds1
Summary
InnateDB Protein IDBP-183922.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cds1
Protein Name CDP-diacylglycerol synthase 1
Synonyms 4833409J18Rik; AI314024; AW125888;
Species Mus musculus
Ensembl Protein ENSMUSP00000031273
InnateDB Gene IDBG-183920 (Cds1)
Protein Structure
UniProt Annotation
Function Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Cytoplasmic aspect of the endoplasmic reticulum. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the inner segment of the photoreceptor layer of adult retina. {ECO:0000269PubMed:9889000}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004605 phosphatidate cytidylyltransferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0016024 CDP-diacylglycerol biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1921846
InterPro IPR000374 Phosphatidate cytidylyltransferase
IPR016720 Phosphatidate cytidylyltransferase, eukaryota
PFAM PF01148
PRINTS
PIRSF PIRSF018269
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P98191
PhosphoSite PhosphoSite-P98191
TrEMBL
UniProt Splice Variant
Entrez Gene 74596
UniGene Mm.46764
RefSeq NP_775546
MGI ID
MGI Symbol Cds1
OMIM
CCDS CCDS19472
HPRD
IMGT
EMBL AF533367 BC055292
GenPept AAH55292 AAO16167

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca