InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPL21

Summary

InnateDB Protein

IDBP-18395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL21

Protein Name

ribosomal protein L21

Synonyms

HYPT12; L21;

Species

Homo sapiens

Ensembl Protein

ENSP00000351021

InnateDB Gene

IDBG-18389 (RPL21)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Note=Defects in RPL21 are a cause of generalized hypotrichosis simplex (HTS). A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.

Experimentally validated
Total	121 [view]
Protein-Protein	121 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit