InnateDB Protein
|
IDBP-184246.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Cnot1
|
Protein Name
|
CCR4-NOT transcription complex, subunit 1
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000096073
|
InnateDB Gene
|
IDBG-184242 (Cnot1)
|
Protein Structure
|
|
Function |
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. {ECO:0000269PubMed:22367759}.
|
Subcellular Localization |
Cytoplasm, P-body {ECO:0000269PubMed:20133598}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=NANOS2 promotes its localization to P-body.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
12
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
40 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0001829
|
trophectodermal cell differentiation
|
GO:0006351
|
transcription, DNA-templated
|
GO:0006417
|
regulation of translation
|
GO:0010606
|
positive regulation of cytoplasmic mRNA processing body assembly
|
GO:0031047
|
gene silencing by RNA
|
GO:0033147
|
negative regulation of intracellular estrogen receptor signaling pathway
|
GO:0048387
|
negative regulation of retinoic acid receptor signaling pathway
|
GO:0060213
|
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
|
GO:0090503
|
RNA phosphodiester bond hydrolysis, exonucleolytic
|
GO:1900153
|
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
|
GO:2000036
|
regulation of stem cell maintenance
|
|
Cellular Component |
|
PDB ID |
MGI:2442402
|
InterPro |
IPR007196
CCR4-Not complex component, Not1, C-terminal
IPR016024
Armadillo-type fold
|
PFAM |
PF04054
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6ZQ08
|
PhosphoSite |
PhosphoSite-Q6ZQ08
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
620499
|
UniGene |
Mm.415682
|
RefSeq |
NP_835179
|
MGI ID |
|
MGI Symbol |
Cnot1
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AC113951
AC127300
AK031357
AK034776
AK048177
AK129258
AK143651
BC018281
BC158073
|
GenPept |
AAH18281
AAI58074
BAC27364
BAC28830
BAC33267
BAC98068
BAE25479
|
|
|