InnateDB Protein
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IDBP-184570.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gm10094
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Protein Name
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predicted gene 10094
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Synonyms
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C530046K05Rik; D11Ertd539e; EMegR4; Sinbp1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000073697
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InnateDB Gene
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IDBG-184568 (Gm10094)
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Protein Structure
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Function |
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Colocalizes with ACIN1 and SRSF2 in nuclear speckles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues tested; highest levels in the brain, kidney and muscle; lowest levels in lung spleen, liver, intestine and testis, and moderate levels in salivary gland and heart. {ECO:0000269PubMed:9511770}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
104 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3704317
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InterPro |
IPR010516
Sin3 associated polypeptide p18
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PFAM |
PF06487
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O55128
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PhosphoSite |
PhosphoSite-O55128
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TrEMBL |
Q4FZH3
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UniProt Splice Variant |
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Entrez Gene |
20220
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UniGene |
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RefSeq |
NP_001135913
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MGI ID |
4A90
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MGI Symbol |
Gm10094
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OMIM |
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CCDS |
CCDS52642
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HPRD |
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IMGT |
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EMBL |
AC119813
AC127300
AK005189
AK006647
AK085992
AK133619
AK144904
AK146928
BC006625
BC099480
CH466525
CH466535
Z97062
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GenPept |
AAH06625
AAH99480
BAB23871
BAB24687
BAC39588
BAE21751
BAE26125
BAE27539
CAB09797
EDL11186
EDL36164
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