InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Calcrl

Summary

InnateDB Protein

IDBP-184607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calcrl

Protein Name

calcitonin receptor-like

Synonyms

AV071593; CRLR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073875

InnateDB Gene

IDBG-184603 (Calcrl)

Protein Structure

UniProt Annotation

Function

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed predominantly in the lung, thymus, heart and brain. {ECO:0000269PubMed:10777702, ECO:0000269PubMed:12147211}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001605	adrenomedullin receptor activity
GO:0001635	calcitonin gene-related polypeptide receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0001525	angiogenesis
GO:0006171	cAMP biosynthetic process
GO:0006816	calcium ion transport
GO:0006937	regulation of muscle contraction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0071329	cellular response to sucrose stimulus

Cellular Component

GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1926944

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001688 GPCR, family 2, calcitonin receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003287 GPCR, family 2, calcitonin receptor family
IPR003289 GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR00361
PR01350
PR01351

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt