InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clic5

Summary

InnateDB Protein

IDBP-184860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clic5

Protein Name

chloride intracellular channel 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024755

InnateDB Gene

IDBG-184858 (Clic5)

Protein Structure

UniProt Annotation

Function

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of stereocilia in the inner ear and normal development of the organ of Corti. {ECO:0000269PubMed:17021174}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.

Disease Associations

Note=Defects in Clic5 are a cause of the jitterbug (jbg) phenotype. Jbg is the result of a spontaneous mutation that leads to severe degeneration of the organ of Corti in the inner ear. Jbg leads to progressive degeneration of inner ear hair cells. Affected mice are identified by head bobbing, circling behavior and their inability to swim. They cannot hear well when young, and become completely deaf after 5 months. {ECO:0000269PubMed:17021174}.

Tissue Specificity

Detected in lung and inner ear. Detected in embryonic cochlea, on microvilli-covered apical surfaces of interdental cells, columnar cells of Kolliker's organ, and on stereocilia of inner and outer hair cells (at protein level). {ECO:0000269PubMed:17021174}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0002021	response to dietary excess
GO:0002024	diet induced thermogenesis
GO:0006821	chloride transport
GO:0007605	sensory perception of sound
GO:0008104	protein localization
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0050885	neuromuscular process controlling balance
GO:0060088	auditory receptor cell stereocilium organization
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005815	microtubule organizing center
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0032420	stereocilium
GO:0032421	stereocilium bundle
GO:0034707	chloride channel complex
GO:0070062	extracellular vesicular exosome