InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcna2

Summary

InnateDB Protein

IDBP-185046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcna2

Protein Name

potassium voltage-gated channel, shaker-related subfamily, member 2

Synonyms

Akr6a4; ENSMUSG00000074335; Gm10672; Kca1-2; Kv1.2; Mk-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041702

InnateDB Gene

IDBG-185044 (Kcna2)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Regulates neuronal excitability and is involved in non-rapid eye movement (NREM) sleep.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity

Biological Process

GO:0006811	ion transport
GO:0021633	optic nerve structural organization
GO:0034765	regulation of ion transmembrane transport
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0044224	juxtaparanode region of axon

Protein Structure and Domains

PDB ID

MGI:96659

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003280 Two pore domain potassium channel
IPR003968 Potassium channel, voltage dependent, Kv
IPR003972 Potassium channel, voltage dependent, Kv1
IPR004048 Potassium channel, voltage dependent, Kv1.1
IPR004049 Potassium channel, voltage dependent, Kv1.2
IPR004050 Potassium channel, voltage dependent, Kv1.3
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain

PFAM

PF02214
PF00520
PF07885

PRINTS