Mus musculus Gene: Kcna2
Summary
InnateDB Gene IDBG-185044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcna2
Gene Name potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms Akr6a4; ENSMUSG00000074335; Gm10672; Kca1-2; Kv1.2; Mk-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000040724
Encoded Proteins
potassium voltage-gated channel, shaker-related subfamily, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177301:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:107101567-107106879
Strand Forward strand
Band F2.3
Transcripts
ENSMUST00000038695 ENSMUSP00000041702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0021633 optic nerve structural organization
GO:0034765 regulation of ion transmembrane transport
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0044224 juxtaparanode region of axon
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Potassium Channels pathway
Neuronal System pathway
Voltage gated Potassium channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Neuronal System pathway
Voltage gated Potassium channels pathway
Potassium Channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P63141
TrEMBL B2RS05
UniProt Splice Variant
Entrez Gene 16490
UniGene Mm.39285 Mm.397905 Mm.56930
RefSeq NM_008417 XM_006501048 XM_006501049 XM_006501050 XM_006501051 XM_006501052 XM_006501053 XM_006501054 XM_006501055
OMIM
CCDS CCDS17733
HPRD
IMGT
MGI ID MGI:96659
MGI Symbol Kcna2
EMBL AK044342 BC138650 BC138651 CH466607 M30440
GenPept AAA39713 AAI38651 AAI38652 BAC31877 EDL01892
RNA Seq Atlas 16490