InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcna2

Summary

InnateDB Gene

IDBG-185044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcna2

Gene Name

potassium voltage-gated channel, shaker-related subfamily, member 2

Synonyms

Akr6a4; ENSMUSG00000074335; Gm10672; Kca1-2; Kv1.2; Mk-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040724

Encoded Proteins

IDBP-185046

potassium voltage-gated channel, shaker-related subfamily, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177301:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:107101567-107106879

Strand

Forward strand

Band

F2.3

Transcripts

ENSMUST00000038695

ENSMUSP00000041702

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity

Biological Process

GO:0006811	ion transport
GO:0021633	optic nerve structural organization
GO:0034765	regulation of ion transmembrane transport
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0044224	juxtaparanode region of axon

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000177301

View Gene Order

ENSBTAG00000015459

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

REACT_199077

Voltage gated Potassium channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P63141

TrEMBL

B2RS05

UniProt Splice Variant

Entrez Gene

16490

UniGene

Mm.39285 Mm.397905 Mm.56930

RefSeq

NM_008417 XM_006501048 XM_006501049 XM_006501050 XM_006501051 XM_006501052 XM_006501053 XM_006501054 XM_006501055

OMIM

CCDS

CCDS17733

HPRD

IMGT

MGI ID

MGI:96659

MGI Symbol

Kcna2

EMBL

AK044342 BC138650 BC138651 CH466607 M30440

GenPept

AAA39713 AAI38651 AAI38652 BAC31877 EDL01892

RNA Seq Atlas

16490