InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ofd1

Summary

InnateDB Protein

IDBP-185284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ofd1

Protein Name

oral-facial-digital syndrome 1 gene homolog (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041744

InnateDB Gene

IDBG-185282 (Ofd1)

Protein Structure

UniProt Annotation

Function

Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation. {ECO:0000269PubMed:18084282, ECO:0000269PubMed:20230748}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body. Nucleus {ECO:0000250}. Note=Localizes to centriole distal ends and to centriolar satellites.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043014	alpha-tubulin binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0010172	embryonic body morphogenesis
GO:0035082	axoneme assembly
GO:0060271	cilium morphogenesis
GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry
GO:2000314	negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005814	centriole
GO:0005929	cilium
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body