InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ofd1

Summary

InnateDB Gene

IDBG-185282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ofd1

Gene Name

oral-facial-digital syndrome 1 gene homolog (human)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040586

Encoded Proteins

IDBP-185284

oral-facial-digital syndrome 1 gene homolog (human)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000046651:
This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. Alternatively spliced transcripts have been described for this gene but the biological validity of these transcripts has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:166390033-166440704

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049501

ENSMUSP00000041744

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043014	alpha-tubulin binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0010172	embryonic body morphogenesis
GO:0035082	axoneme assembly
GO:0060271	cilium morphogenesis
GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry
GO:2000314	negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005814	centriole
GO:0005929	cilium
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body