InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alx3

Summary

InnateDB Protein

IDBP-185349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alx3

Protein Name

aristaless-like homeobox 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014747

InnateDB Gene

IDBG-185347 (Alx3)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator with a possible role in patterning of mesoderm during development.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Prominent expression in frontonasal head mesenchyme and in the first and second pharyngeal arches and some of their derivatives. High expression is also seen in the tail and in many derivatives of the lateral plate mesoderm including the limbs, the body wall, and the genital tubercle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0042981	regulation of apoptotic process
GO:0048704	embryonic skeletal system morphogenesis