InnateDB Protein
|
IDBP-185394.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Dmp1
|
Protein Name
|
dentin matrix protein 1
|
Synonyms
|
AV020965; Dmp; PP;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000068053
|
InnateDB Gene
|
IDBG-185392 (Dmp1)
|
Protein Structure
|
|
Function |
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in tooth particularly in odontoblast, ameloblast and cementoblast. Also expressed in bone particularly in osteoblast.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0050840
|
extracellular matrix binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:94910
|
InterPro |
IPR009889
Dentin matrix 1
|
PFAM |
PF07263
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O55188
|
PhosphoSite |
PhosphoSite-O55188
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
13406
|
UniGene |
Mm.416408
|
RefSeq |
NP_058059
|
MGI ID |
|
MGI Symbol |
Dmp1
|
OMIM |
|
CCDS |
CCDS19484
|
HPRD |
|
IMGT |
|
EMBL |
AJ242625
AK132177
AK157973
CH466529
U65020
|
GenPept |
AAB93764
BAE21014
BAE34293
CAB59629
EDL20228
|
|
|