Version 5.4
| Mus musculus Gene: Dmp1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-185392.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Dmp1 | ||||||||||
| Gene Name | dentin matrix protein 1 | ||||||||||
| Synonyms | AV020965; Dmp; PP | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000029307 | ||||||||||
| Encoded Proteins |
dentin matrix protein 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152592:
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 5:104202617-104214102 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | E5 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Extracellular matrix organization pathway
ECM proteoglycans pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Extracellular matrix organization pathway
ECM proteoglycans pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI |
AP-1 transcription factor network
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| Cross-References | |||||||||||
| SwissProt | O55188 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 13406 | ||||||||||
| UniGene | Mm.199008 Mm.416408 | ||||||||||
| RefSeq | NM_016779 XM_006534766 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS19484 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:94910 | ||||||||||
| MGI Symbol | Dmp1 | ||||||||||
| EMBL | AJ242625 AK132177 AK157973 CH466529 U65020 | ||||||||||
| GenPept | AAB93764 BAE21014 BAE34293 CAB59629 EDL20228 | ||||||||||
| RNA Seq Atlas | 13406 | ||||||||||