Version 5.4
Mus musculus Protein: Slc29a1
Summary
InnateDB Protein IDBP-185542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc29a1
Protein Name solute carrier family 29 (nucleoside transporters), member 1
Synonyms 1200014D21Rik; AA407560; ENT1;
Species Mus musculus
Ensembl Protein ENSMUSP00000063757
InnateDB Gene IDBG-185538 (Slc29a1)
Protein Structure
UniProt Annotation
Function Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).
Subcellular Localization Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in heart, spleen, lung, liver and testis. Lower level of expression in brain and kidney. {ECO:0000269PubMed:11027664}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005337 nucleoside transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0007595 lactation
GO:0015858 nucleoside transport
GO:0015862 uridine transport
GO:0030431 sleep
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071333 cellular response to glucose stimulus
GO:0071456 cellular response to hypoxia
GO:1901642 nucleoside transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID MGI:1927073
InterPro IPR002259 Equilibrative nucleoside transporter
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF01733
PRINTS PR01130
PIRSF PIRSF016379
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JIM1
PhosphoSite PhosphoSite-Q9JIM1
TrEMBL Q3TCZ2
UniProt Splice Variant
Entrez Gene 63959
UniGene Mm.29744
RefSeq NP_001186045
MGI ID
MGI Symbol Slc29a1
OMIM
CCDS CCDS28813
HPRD
IMGT
EMBL AC163677 AF131212 AF218255 AF305501 AK004756 AK050089 AK149483 AK170463 BC004828 BC006812 CH466559
GenPept AAF64035 AAF64036 AAF78452 AAG22828 AAH04828 AAH06812 BAB23537 BAC34063 BAE28909 BAE41813 EDL23451 EDL23452 EDL23454 EDL23456

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca