InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prg2

Summary

InnateDB Protein

IDBP-185621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prg2

Protein Name

proteoglycan 2, bone marrow

Synonyms

MBP; mMBP; mMBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028467

InnateDB Gene

IDBG-185619 (Prg2)

Protein Structure

UniProt Annotation

Function

Cytotoxin and helminthotoxin. MBP also induces non- cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic granule {ECO:0000250}. Note=Matrix of eosinophil's large specific granule (crystalloid core). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030246	carbohydrate binding

Biological Process

GO:0002215	defense response to nematode
GO:0006955	immune response
GO:0032693	negative regulation of interleukin-10 production
GO:0032753	positive regulation of interleukin-4 production
GO:0042742	defense response to bacterium