Version 5.4
Mus musculus Gene: Prg2
Summary
InnateDB Gene IDBG-185619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prg2
Gene Name proteoglycan 2, bone marrow
Synonyms MBP; mMBP; mMBP-1
Species Mus musculus
Ensembl Gene ENSMUSG00000027073
Encoded Proteins
IDBP-185621
proteoglycan 2, bone marrow
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186652:
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:84980461-84983632
Strand Forward strand
Band D
Transcripts
ENSMUST00000028467 ENSMUSP00000028467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0002215 defense response to nematode
GO:0006955 immune response
GO:0032693 negative regulation of interleukin-10 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042742 defense response to bacterium
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000186652
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu05310
Asthma pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05310
Asthma pathway
INOH
PID NCI
Cross-References
SwissProt Q61878
TrEMBL Q545D8
UniProt Splice Variant
Entrez Gene 19074
UniGene Mm.142727
RefSeq NM_008920
OMIM
CCDS CCDS16198
HPRD
IMGT
MGI ID MGI:103294
MGI Symbol Prg2
EMBL AK010901 AK156715 BC109348 CH466519 L46768
GenPept AAA83027 AAI09349 BAB27254 BAE33816 EDL27312
RNA Seq Atlas 19074

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca