InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elk3

Summary

InnateDB Protein

IDBP-185814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elk3

Protein Name

ELK3, member of ETS oncogene family

Synonyms

D430049E23Rik; Erp; Etrp; Net; Sap-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008542

InnateDB Gene

IDBG-185812 (Elk3)

Protein Structure

UniProt Annotation

Function

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Heart, liver, lung, kidney and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0032422	purine-rich negative regulatory element binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001525	angiogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0042060	wound healing
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter