InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EBI3

Summary

InnateDB Protein

IDBP-18582.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EBI3

Protein Name

Epstein-Barr virus induced 3

Synonyms

IL-27B; IL27B;

Species

Homo sapiens

Ensembl Protein

ENSP00000221847

InnateDB Gene

IDBG-18580 (EBI3)

Protein Structure

UniProt Annotation

Function

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. {ECO:0000269PubMed:12121660}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0045523	interleukin-27 receptor binding

Biological Process

GO:0006959	humoral immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0042088	T-helper 1 type immune response
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0046641	positive regulation of alpha-beta T cell proliferation