Version 5.4
Homo sapiens Gene: EBI3
Summary
InnateDB Gene IDBG-18580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EBI3
Gene Name Epstein-Barr virus induced 3
Synonyms IL-27B; IL27B
Species Homo sapiens
Ensembl Gene ENSG00000105246
Encoded Proteins
IDBP-18582
Epstein-Barr virus induced 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4229498-4237531
Strand Forward strand
Band p13.3
Transcripts
ENST00000221847 ENSP00000221847
ENST00000599339
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045523 interleukin-27 receptor binding
Biological Process
GO:0006959 humoral immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0042088 T-helper 1 type immune response
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0046641 positive regulation of alpha-beta T cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003206
View Gene Order
ENSBTAG00000012829
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
il27pathway
IL27-mediated signaling events
Cross-References
SwissProt Q14213
TrEMBL
UniProt Splice Variant
Entrez Gene 10148
UniGene
RefSeq NM_005755
HUGO HGNC:3129
OMIM 605816
CCDS CCDS12123
HPRD
IMGT
EMBL AC005578 BC015364 BC046112 CH471139 EF064740 L08187
GenPept AAA93193 AAC33488 AAH15364 AAH46112 ABK41923 EAW69245
RNA Seq Atlas 10148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca