Version 5.4
Mus musculus Protein: Necap1
Summary
InnateDB Protein IDBP-185934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Necap1
Protein Name NECAP endocytosis associated 1
Synonyms 1200016B17Rik; AI747569; mFLJ00061;
Species Mus musculus
Ensembl Protein ENSMUSP00000032477
InnateDB Gene IDBG-185932 (Necap1)
Protein Structure
UniProt Annotation
Function Involved in endocytosis. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269PubMed:14555962}. Cell membrane {ECO:0000269PubMed:14555962}. Note=Colocalizes with AP-2 at the plasma membrane.
Disease Associations
Tissue Specificity Expressed primarily in brain (at protein level). {ECO:0000269PubMed:14555962}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030125 clathrin vesicle coat
Protein Structure and Domains
PDB ID MGI:1914852
InterPro IPR012466 Adaptin ear-binding coat-associated protein 1 NECAP-1
PFAM PF07933
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CR95
PhosphoSite PhosphoSite-Q9CR95
TrEMBL Q0VB06
UniProt Splice Variant
Entrez Gene 67602
UniGene Mm.415849
RefSeq NP_080543
MGI ID 1TQZ
MGI Symbol Necap1
OMIM
CCDS CCDS20505
HPRD
IMGT
EMBL AK004805 AK005263 AK081598 AK168500 BC011466 BC119133 BC120841 BK000656 CH466523
GenPept AAH11466 AAI19134 AAI20842 BAB23577 BAB23915 BAC38266 BAE40385 DAA01433 EDK99699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca