Version 5.4
Mus musculus Gene: Necap1
Summary
InnateDB Gene IDBG-185932.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Necap1
Gene Name NECAP endocytosis associated 1
Synonyms 1200016B17Rik; AI747569; mFLJ00061
Species Mus musculus
Ensembl Gene ENSMUSG00000030327
Encoded Proteins
IDBP-185934
NECAP endocytosis associated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089818:
This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:122874557-122888934
Strand Forward strand
Band F2
Transcripts
ENSMUST00000032477 ENSMUSP00000032477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0015031 protein transport
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030125 clathrin vesicle coat
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000089818
View Gene Order
ENSBTAG00000020237
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
REACT_219531
Golgi Associated Vesicle Biogenesis pathway
REACT_216751
Clathrin derived vesicle budding pathway
REACT_211153
trans-Golgi Network Vesicle Budding pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9CR95
TrEMBL Q0VB06
UniProt Splice Variant
Entrez Gene 67602
UniGene Mm.288114 Mm.415849
RefSeq NM_026267
OMIM
CCDS CCDS20505
HPRD
IMGT
MGI ID MGI:1914852
MGI Symbol Necap1
EMBL AK004805 AK005263 AK081598 AK168500 BC011466 BC119133 BC120841 BK000656 CH466523
GenPept AAH11466 AAI19134 AAI20842 BAB23577 BAB23915 BAC38266 BAE40385 DAA01433 EDK99699
RNA Seq Atlas 67602

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca