InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr2c1

Summary

InnateDB Protein

IDBP-186605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr2c1

Protein Name

nuclear receptor subfamily 2, group C, member 1

Synonyms

4831444H07Rik; 80.3; Eenr; TR2; Tr2-11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089858

InnateDB Gene

IDBG-186603 (Nr2c1)

Protein Structure

UniProt Annotation

Function

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. {ECO:0000250, ECO:0000269PubMed:11463856, ECO:0000269PubMed:12093744, ECO:0000269PubMed:16130175, ECO:0000269PubMed:16317770, ECO:0000269PubMed:17187077, ECO:0000269PubMed:17389641, ECO:0000269PubMed:17431400, ECO:0000269PubMed:17974920, ECO:0000269PubMed:19131575, ECO:0000269PubMed:8530418, ECO:0000269PubMed:8858600, ECO:0000269PubMed:9071982, ECO:0000269PubMed:9774688}.

Subcellular Localization

Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation.

Disease Associations

Tissue Specificity

Isoform 1 is highly expressed in the adlumenal compartment of the seminiferous tubule of adult testes (at protein level) and in the eyes of newborn animals. Weakly expressed in other adult organs including the seminal vesicle, prostate, ovary, adrenal gland, heart, thymus, placenta and brain. Expressed during embryonic stages in developing eyes, brain and cartilage primordia (at protein level). Also expressed in the developing spinal motor neurons and in the sympathetic-, parasympathetic- and sensory ganglia of the embryonic PNS. Expressed in the developing neural epithelia of the inner ear, nasal cavity, tongue and retina. At day 16.5, expressed in various tissues including kidney and intestine. In contrast, isoform 2 is widely expressed at a low level throughout the adult testis. {ECO:0000269PubMed:12052874, ECO:0000269PubMed:8530418, ECO:0000269PubMed:8595902, ECO:0000269PubMed:8858600, ECO:0000269PubMed:9071982, ECO:0000269PubMed:9504722, ECO:0000269PubMed:9694834}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048386	positive regulation of retinoic acid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0016605	PML body

Protein Structure and Domains

PDB ID

MGI:1352465

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt