InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krt2

Summary

InnateDB Protein

IDBP-186948.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krt2

Protein Name

keratin 2

Synonyms

BB005427; Krt2-17; Krt2-2; Krt2e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023712

InnateDB Gene

IDBG-186946 (Krt2)

Protein Structure

UniProt Annotation

Function

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization (By similarity). {ECO:0000250UniProtKB:P35908}.

Subcellular Localization

Disease Associations

Note=Defects in Krt2 are a cause of ichthyosis bullosa of siemens (IBS). IBS is a rare autosomal dominant disorder displaying a type of epidermolytic hyperkeratosis characterized by extensive blistering from birth. Hyperkeratoses and shedding of the outer layers of the epidermis (molting) are observed in later weeks.

Tissue Specificity

Expressed mainly in the middle spinous and granular cells of the epidermis of adult tail, nipple and footsole skin. Also found in ear. {ECO:0000269PubMed:15118396, ECO:0000269PubMed:2448177, ECO:0000269PubMed:7508961}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0005198	structural molecule activity

Biological Process

GO:0008150	biological_process
GO:0031424	keratinization
GO:0032980	keratinocyte activation
GO:0043616	keratinocyte proliferation
GO:0051546	keratinocyte migration

Cellular Component

GO:0005575	cellular_component
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0045095	keratin filament
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome