InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rap2a

Summary

InnateDB Protein

IDBP-187474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rap2a

Protein Name

RAS related protein 2a

Synonyms

5830461H18Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056433

InnateDB Gene

IDBG-187472 (Rap2a)

Protein Structure

UniProt Annotation

Function

Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. {ECO:0000269PubMed:12133960, ECO:0000269PubMed:18701680, ECO:0000269PubMed:19061864}.

Subcellular Localization

Midbody {ECO:0000250}. Recycling endosome membrane {ECO:0000269PubMed:19061864}; Lipid-anchor {ECO:0000269PubMed:19061864}; Cytoplasmic side {ECO:0000269PubMed:19061864}. Note=Localizes to midbody at telophase. May also localize to the Golgi and the gelatinase- containing granules of neutrophils. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in granular layer of the cerebellum, forebrain, striatum, layer V of the cortex, olfactory cortex, tubercules, subthalamic and hippocampus, particularly in the CA2 region, to a lesser extent in the CA1 region and the external layer of the dentate gyrus. Expressed in neurons. {ECO:0000269PubMed:10926822}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0015684	ferrous iron transport
GO:0030336	negative regulation of cell migration
GO:0031532	actin cytoskeleton reorganization
GO:0031954	positive regulation of protein autophosphorylation
GO:0032486	Rap protein signal transduction
GO:0034613	cellular protein localization
GO:0045184	establishment of protein localization
GO:0046328	regulation of JNK cascade
GO:0048814	regulation of dendrite morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030496	midbody
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97855

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF02421
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt