InnateDB Protein
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IDBP-187512.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Phb2
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Protein Name
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prohibitin 2
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Synonyms
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AU044498; BAP; Bap37; Bcap37; REA;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000004375
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InnateDB Gene
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IDBG-187510 (Phb2)
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Protein Structure
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Function |
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. {ECO:0000250UniProtKB:Q99623, ECO:0000269PubMed:12878603, ECO:0000269PubMed:15140878}.
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Subcellular Localization |
Mitochondrion inner membrane. Cytoplasm. Nucleus. Note=Also cytoplasmic and nuclear.
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Disease Associations |
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Tissue Specificity |
Widely expressed in different tissues. {ECO:0000269PubMed:11302691, ECO:0000269PubMed:15140878, ECO:0000269PubMed:8070406}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
73 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0033147
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negative regulation of intracellular estrogen receptor signaling pathway
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GO:0033600
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negative regulation of mammary gland epithelial cell proliferation
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0060744
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mammary gland branching involved in thelarche
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GO:0060749
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mammary gland alveolus development
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GO:0060762
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regulation of branching involved in mammary gland duct morphogenesis
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Cellular Component |
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PDB ID |
MGI:102520
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InterPro |
IPR000163
Prohibitin
IPR001107
Band 7 protein
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PFAM |
PF01145
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PRINTS |
PR00679
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PIRSF |
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SMART |
SM00244
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TIGRFAMs |
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Modification |
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SwissProt |
O35129
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PhosphoSite |
PhosphoSite-O35129
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TrEMBL |
Q3V235
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UniProt Splice Variant |
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Entrez Gene |
12034
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UniGene |
Mm.489173
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RefSeq |
NP_031557
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MGI ID |
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MGI Symbol |
Phb2
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OMIM |
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CCDS |
CCDS39627
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HPRD |
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IMGT |
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EMBL |
AC002397
AK132052
AK132058
AK151952
AY211613
AY319418
BC145875
U89422
X78683
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GenPept |
AAC36005
AAC36528
AAI45876
AAP47231
AAP86652
BAE20962
BAE20964
BAE30825
CAA55350
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