Version 5.4
Mus musculus Protein: Farp1
Summary
InnateDB Protein IDBP-187668.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Farp1
Protein Name FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000026635
InnateDB Gene IDBG-187664 (Farp1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0008092 cytoskeletal protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0007416 synapse assembly
GO:0010923 negative regulation of phosphatase activity
GO:0032314 regulation of Rac GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030425 dendrite
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043197 dendritic spine
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:2446173
InterPro IPR000219 Dbl homology (DH) domain
IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR001849 Pleckstrin homology domain
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain
PFAM PF00621
PF00169
PF08736
PF09379
PF09380
PF00373
PRINTS PR00661
PR00935
PIRSF
SMART SM00325
SM00233
SM00295
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt F8VPU2
PhosphoSite PhosphoSite-NP_598843
TrEMBL Q8R2X2
UniProt Splice Variant
Entrez Gene 223254
UniGene Mm.490290
RefSeq NP_598843
MGI ID
MGI Symbol Farp1
OMIM
CCDS CCDS37015
HPRD
IMGT
EMBL AC154618 AC165163 AC167566 AK034903 BC027077 BC043327 BC141229
GenPept AAH27077 AAH43327 AAI41230 BAC28875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca