InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnmt

Summary

InnateDB Protein

IDBP-188308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnmt

Protein Name

glycine N-methyltransferase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002846

InnateDB Gene

IDBG-188306 (Gnmt)

Protein Structure

UniProt Annotation

Function

Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005542	folic acid binding
GO:0008168	methyltransferase activity
GO:0016594	glycine binding
GO:0017174	glycine N-methyltransferase activity

Biological Process

GO:0005977	glycogen metabolic process
GO:0006111	regulation of gluconeogenesis
GO:0006555	methionine metabolic process
GO:0006730	one-carbon metabolic process
GO:0008152	metabolic process
GO:0032259	methylation
GO:0046500	S-adenosylmethionine metabolic process
GO:0051289	protein homotetramerization

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1202304

InterPro

IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR014369 Glycine/Sarcosine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF08241
PF08242

PRINTS

PIRSF

PIRSF000385

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QXF8