Version 5.4
Mus musculus Gene: Gnmt
Summary
InnateDB Gene IDBG-188306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnmt
Gene Name glycine N-methyltransferase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000002769
Encoded Proteins
IDBP-188308
glycine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124713:
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46725664-46729168
Strand Reverse strand
Band C
Transcripts
ENSMUST00000002846 ENSMUSP00000002846
ENSMUST00000147112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005542 folic acid binding
GO:0008168 methyltransferase activity
GO:0016594 glycine binding
GO:0017174 glycine N-methyltransferase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006555 methionine metabolic process
GO:0006730 one-carbon metabolic process
GO:0008152 metabolic process
GO:0032259 methylation
GO:0046500 S-adenosylmethionine metabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124713
View Gene Order
ENSBTAG00000005530
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt Q9QXF8
TrEMBL Q8C4E3
UniProt Splice Variant
Entrez Gene 14711
UniGene
RefSeq NM_010321
OMIM
CCDS CCDS28838
HPRD
IMGT
MGI ID MGI:1202304
MGI Symbol Gnmt
EMBL AF325352 AK082459 AY054408 BC014283 D89664
GenPept AAH14283 AAK00338 AAL06142 BAA88218 BAC38496
RNA Seq Atlas 14711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca