InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dgkq

Summary

InnateDB Protein

IDBP-188376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgkq

Protein Name

diacylglycerol kinase, theta

Synonyms

110kDa; DAGK; Dagk4; DAGK7; Dgkd;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057859

InnateDB Gene

IDBG-188374 (Dgkq)

Protein Structure

UniProt Annotation

Function

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Translocates to the nucleus in response to thrombin stimulation. Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0033613	activating transcription factor binding
GO:0043274	phospholipase binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0033198	response to ATP
GO:0035556	intracellular signal transduction
GO:0070493	thrombin receptor signaling pathway
GO:0070528	protein kinase C signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

MGI:102918

InterPro

IPR000159 Ras-association
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020454 Diacylglycerol/phorbol-ester binding
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00609
PF00781
PF00130

PRINTS

PR00008

PIRSF

SMART

SM00314
SM00045
SM00046
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt