InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dgkq

Summary

InnateDB Gene

IDBG-188374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dgkq

Gene Name

diacylglycerol kinase, theta

Synonyms

110kDa; DAGK; Dagk4; DAGK7; Dgkd

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004815

Encoded Proteins

IDBP-188376

diacylglycerol kinase, theta

IDBP-533037

diacylglycerol kinase, theta

IDBP-539371

diacylglycerol kinase, theta

IDBP-534847

diacylglycerol kinase, theta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145214:
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:108646693-108669672

Strand

Reverse strand

Band

Transcripts

ENSMUST00000053913	ENSMUSP00000057859
ENSMUST00000153238	ENSMUSP00000118065
ENSMUST00000144624
ENSMUST00000132179	ENSMUSP00000118466
ENSMUST00000132708	ENSMUSP00000122837
ENSMUST00000153365
ENSMUST00000123669
ENSMUST00000145917
ENSMUST00000139169
ENSMUST00000156964
ENSMUST00000139598

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0033613	activating transcription factor binding
GO:0043274	phospholipase binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016310	phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0033198	response to ATP
GO:0035556	intracellular signal transduction
GO:0070493	thrombin receptor signaling pathway
GO:0070528	protein kinase C signaling