Version 5.4
| Mus musculus Protein: Col8a2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-188400.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Col8a2 | ||||||||
| Protein Name | collagen, type VIII, alpha 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000070270 | ||||||||
| InnateDB Gene | IDBG-188398 (Col8a2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. {ECO:0000269PubMed:19401424}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:88464 | ||||||||
| InterPro |
IPR001073
Complement C1q protein IPR008160 Collagen triple helix repeat IPR008983 Tumour necrosis factor-like domain |
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| PFAM |
PF00386
PF01391 |
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| PRINTS |
PR00007
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| PIRSF | |||||||||
| SMART |
SM00110
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P25318 | ||||||||
| PhosphoSite | PhosphoSite-P25318 | ||||||||
| TrEMBL | A3KFY1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 329941 | ||||||||
| UniGene | Mm.395267 | ||||||||
| RefSeq | NP_955767 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Col8a2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18649 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK131153 AL606976 BC065148 BC080317 M60833 | ||||||||
| GenPept | AAH65148 AAH80317 BAD21403 CAM45876 | ||||||||