Version 5.4
Mus musculus Protein: Prph2
Summary
InnateDB Protein IDBP-188528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prph2
Protein Name peripherin 2
Synonyms AOFMD; AVMD; Nmf193; PRPH; Rd-2; Rd2; Rds; rds; RP7; Tspan22;
Species Mus musculus
Ensembl Protein ENSMUSP00000024773
InnateDB Gene IDBG-188526 (Prph2)
Protein Structure
UniProt Annotation
Function May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations Note=Responsible for retinal degeneration slow (Rds).
Tissue Specificity Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0007601 visual perception
GO:0009645 response to low light intensity stimulus
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:102791
InterPro IPR000830 Peripherin/rom-1
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00218
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15499
PhosphoSite PhosphoSite-
TrEMBL Q3UWK3
UniProt Splice Variant
Entrez Gene 19133
UniGene
RefSeq NP_032964
MGI ID
MGI Symbol Prph2
OMIM
CCDS CCDS28844
HPRD
IMGT
EMBL AK136280 BC028958 BC085266 CH466559 L42167 X14770
GenPept AAC37674 AAH28958 AAH85266 BAE22911 CAA32878 EDL23547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca