Version 5.4
Mus musculus Protein: Stx8
Summary
InnateDB Protein IDBP-188580.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stx8
Protein Name syntaxin 8
Synonyms 0610007H08Rik; 1110002H11Rik; 4930571E13Rik; CARB;
Species Mus musculus
Ensembl Protein ENSMUSP00000021285
InnateDB Gene IDBG-188576 (Stx8)
Protein Structure
UniProt Annotation
Function Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006906 vesicle fusion
GO:0008333 endosome to lysosome transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031201 SNARE complex
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID MGI:1890156
InterPro IPR000727 Target SNARE coiled-coil domain
PFAM PF05739
PRINTS
PIRSF
SMART SM00397
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88983
PhosphoSite PhosphoSite-O88983
TrEMBL
UniProt Splice Variant
Entrez Gene 55943
UniGene Mm.3973
RefSeq NP_061238
MGI ID
MGI Symbol Stx8
OMIM
CCDS CCDS24863
HPRD
IMGT
EMBL AB040054 AF036716 AF093064 AK003297 AL663076 AL669842 BC048167 BC048479
GenPept AAC64149 AAC95286 AAH48167 AAH48479 BAB20500 BAB22698 CAI24774

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca