InnateDB Protein
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IDBP-18888.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SBDS
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Protein Name
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Shwachman-Bodian-Diamond syndrome
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000246868
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InnateDB Gene
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IDBG-18886 (SBDS)
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Protein Structure
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Function |
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269PubMed:17643419, ECO:0000269PubMed:19602484, ECO:0000269PubMed:19759903, ECO:0000269PubMed:21536732}.
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Subcellular Localization |
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). {ECO:0000269PubMed:19759903}.
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Disease Associations |
Shwachman-Diamond syndrome (SDS) [MIM:260400]: Autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities. {ECO:0000269PubMed:12496757}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002140
Ribosome maturation protein SBDS
IPR018978
Ribosome maturation protein SBDS, C-terminal
IPR019783
Ribosome maturation protein SBDS, N-terminal
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PFAM |
PF09377
PF01172
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y3A5
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PhosphoSite |
PhosphoSite-Q9Y3A5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51119
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UniGene |
Hs.585053
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RefSeq |
NP_057122
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HUGO |
HGNC:19440
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OMIM |
607444
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CCDS |
CCDS5537
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HPRD |
07393
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IMGT |
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EMBL |
AF151855
AK001779
AK289609
AY169963
BC065700
CH471140
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GenPept |
AAD34092
AAH65700
AAN77490
BAA91905
BAF82298
EAX07906
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