InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ibtk

Summary

InnateDB Protein

IDBP-188980.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ibtk

Protein Name

inhibitor of Bruton agammaglobulinemia tyrosine kinase

Synonyms

5430411K16Rik; AA409502; BTKI; mKIAA1417;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041145

InnateDB Gene

IDBG-188976 (Ibtk)

Protein Structure

UniProt Annotation

Function

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane upon IgM stimulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030292	protein tyrosine kinase inhibitor activity

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0061099	negative regulation of protein tyrosine kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1918677

InterPro

IPR000210 BTB/POZ-like
IPR000408 Regulator of chromosome condensation, RCC1
IPR002110 Ankyrin repeat
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00415
PF00023
PF13606
PF00651
PF11929
PF12796

PRINTS

PR00633
PR01415

PIRSF

SMART

SM00225
SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt