Version 5.4
Mus musculus Gene: Ibtk
Summary
InnateDB Gene IDBG-188976.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ibtk
Gene Name inhibitor of Bruton agammaglobulinemia tyrosine kinase
Synonyms 5430411K16Rik; AA409502; BTKI; mKIAA1417
Species Mus musculus
Ensembl Gene ENSMUSG00000035941
Encoded Proteins
IDBP-188980
inhibitor of Bruton agammaglobulinemia tyrosine kinase
IDBP-789839
inhibitor of Bruton agammaglobulinemia tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005700:
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. [provided by RefSeq, Jul 2008]
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK\'s kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:85687360-85749334
Strand Reverse strand
Band E3.1
Transcripts
ENSMUST00000039213 ENSMUSP00000041145
ENSMUST00000187521 ENSMUSP00000139424
ENSMUST00000186322
ENSMUST00000188768
ENSMUST00000185353
ENSMUST00000186447
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030292 protein tyrosine kinase inhibitor activity
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0051209 release of sequestered calcium ion into cytosol
GO:0061099 negative regulation of protein tyrosine kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000005700
View Gene Order
ENSBTAG00000026716
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001081282 XM_006510765 XM_006510766
OMIM
CCDS CCDS40712
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca