InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndel1

Summary

InnateDB Protein

IDBP-189122.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndel1

Protein Name

nuclear distribution gene E-like homolog 1 (A. nidulans)

Synonyms

2600006O07Rik; MITAP1; mNudel; NUDEL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098579

InnateDB Gene

IDBG-189118 (Ndel1)

Protein Structure

UniProt Annotation

Function

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. {ECO:0000269PubMed:12796778, ECO:0000269PubMed:15208636, ECO:0000269PubMed:15473966, ECO:0000269PubMed:16107726, ECO:0000269PubMed:16203747}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore in a CENPF-dependent manner. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Localizes to the interphase centrosome and the mitotic spindle. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, liver, lung and testis (at protein level). Expressed in brain, epididymis, eye, heart, kidney, large intestine, liver, ovary, pancreas, prostate, skeletal muscle, smooth muscle, spleen, submaxillary gland, testis, thymus and thyroid. Within the brain expression is pronounced in the cortex, hippocampus, olfactory bulb, striatum, thalamic and hypothalamic structures and in the molecular layer of the cerebellum. Largely excluded from cortical progenitor cells which express NDE1. {ECO:0000269PubMed:11163259, ECO:0000269PubMed:11163260, ECO:0000269PubMed:11231056, ECO:0000269PubMed:15147871}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding
GO:0070012	oligopeptidase activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0001833	inner cell mass cell proliferation
GO:0006508	proteolysis
GO:0007059	chromosome segregation
GO:0007100	mitotic centrosome separation
GO:0008090	retrograde axon cargo transport
GO:0010975	regulation of neuron projection development
GO:0016477	cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021955	central nervous system neuron axonogenesis
GO:0032864	activation of Cdc42 GTPase activity
GO:0045773	positive regulation of axon extension
GO:0047496	vesicle transport along microtubule
GO:0048680	positive regulation of axon regeneration
GO:0051081	nuclear envelope disassembly
GO:0051642	centrosome localization
GO:0060052	neurofilament cytoskeleton organization
GO:1990138	neuron projection extension

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0030424	axon
GO:0031252	cell leading edge
GO:0043203	axon hillock
GO:0060053	neurofilament cytoskeleton