Mus musculus Protein: Ndel1
InnateDB Protein IDBP-189122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndel1
Protein Name nuclear distribution gene E-like homolog 1 (A. nidulans)
Synonyms 2600006O07Rik; MITAP1; mNudel; NUDEL;
Species Mus musculus
Ensembl Protein ENSMUSP00000098579
InnateDB Gene IDBG-189118 (Ndel1)
Protein Structure
UniProt Annotation
Function Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. {ECO:0000269PubMed:12796778, ECO:0000269PubMed:15208636, ECO:0000269PubMed:15473966, ECO:0000269PubMed:16107726, ECO:0000269PubMed:16203747}.
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore in a CENPF-dependent manner. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Localizes to the interphase centrosome and the mitotic spindle. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, liver, lung and testis (at protein level). Expressed in brain, epididymis, eye, heart, kidney, large intestine, liver, ovary, pancreas, prostate, skeletal muscle, smooth muscle, spleen, submaxillary gland, testis, thymus and thyroid. Within the brain expression is pronounced in the cortex, hippocampus, olfactory bulb, striatum, thalamic and hypothalamic structures and in the molecular layer of the cerebellum. Largely excluded from cortical progenitor cells which express NDE1. {ECO:0000269PubMed:11163259, ECO:0000269PubMed:11163260, ECO:0000269PubMed:11231056, ECO:0000269PubMed:15147871}.
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0001833 inner cell mass cell proliferation
GO:0006508 proteolysis
GO:0007059 chromosome segregation
GO:0007100 mitotic centrosome separation
GO:0008090 retrograde axon cargo transport
GO:0010975 regulation of neuron projection development
GO:0016477 cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021955 central nervous system neuron axonogenesis
GO:0032864 activation of Cdc42 GTPase activity
GO:0045773 positive regulation of axon extension
GO:0047496 vesicle transport along microtubule
GO:0048680 positive regulation of axon regeneration
GO:0051081 nuclear envelope disassembly
GO:0051642 centrosome localization
GO:0060052 neurofilament cytoskeleton organization
GO:1990138 neuron projection extension
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030424 axon
GO:0031252 cell leading edge
GO:0043203 axon hillock
GO:0060053 neurofilament cytoskeleton
Protein Structure and Domains
PDB ID MGI:1932915
InterPro IPR006964 NUDE protein, C-terminal
PFAM PF04880
Post-translational Modifications
SwissProt Q9ERR1
PhosphoSite PhosphoSite-Q9ERR1
UniProt Splice Variant
Entrez Gene 83431
UniGene Mm.470454
RefSeq XP_006534601
MGI Symbol Ndel1
EMBL AF290472 AF323918 AK011168 AL603662 BC021434 BC046796
GenPept AAG10061 AAG42496 AAH21434 AAH46796 BAB27443 CAI25525 CAI25526